![]() Sudden cardiac death (SCD) describes an unexpected death from a cardiac cause, in a person without any prior cardiac conditions. Limitation includes the retrospective nature of the study and that, as arrhythmogenic gene mutations are not yet routinely performed in unexplained deaths, the incidence of SCD in infants and children is most likely underestimated.Įach year, around 47,000 people under the age of 75 in the UK die from heart and circulatory diseases. Several diseases could have been identified earlier in life allowing for the possibility of intervention. This retrospective comparative study represents the largest autopsy series of SCD in infants and children in the UK. Symptoms had been present for a mean of 3.8, 3.0, and 3.5 days before death for myocarditis, cardiomyopathy, and cardiac malformations/complications post-surgery. Prematurity was predominantly associated with deaths related to cardiac malformations ( p < 0.001). ![]() The three most prevalent groups of cardiac pathology were cardiac malformations (51/151 33.8%), cardiomyopathies (32/151 21.2%), and myocarditis (31/151 20.5%). The mean annual incidence of SCD was 0.3 per 100,000 persons/annum. These 151 cases constituted the study cohort. 68/1129 cases of SCD (6.0%) were identified in one center and 83/753 cases (11%) in the other. The study was PRISMA compliant and approved by clinical governance. ![]() All cases of sudden and/or unexpected cardiac deaths (SCD) between 20 were identified. Histological features and results of ancillary investigations were noted. The post-mortem databases of two tertiary referral institutions were searched, and all reports were reviewed. To review post-mortem findings among deaths presenting as sudden and/or unexpected deaths in two centers in the UK during a 16-year period in order to identify those related to cardiovascular conditions. ![]()
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